obesity

Contrary to popular belief, obesity doesn’t result as much from laziness and gluttony than it does from genetics. For most overweight people, keeping the pounds off may be significantly harder because they have genes that predispose them to be larger, or cause them to be more addicted to food. Obesity is a growing worldwide epidemic and an estimated 70% of adults in the US are considered overweight or obese. Both conditions are serious health problems because they exponentially raise the risk of diabetes, heart disease, certain types of cancer and heart failure. Unfortunately, many researchers believe that genetics are responsible for at least 50% of all obesity cases. There is not only one gene that influence this, but a multitude of as much as 30 genes.

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The average population’s risk for obesity is around 35% and the heritability of obesity is estimated to be around 75%, which means genetics are more responsible for a person’s weight than life style and environmental factors. For instance, the well studied FTO gene accounts for an extra 6.6 pounds of difference in weight. Unfortunately, even if you are not at a genetic risk for obesity, a sedentary life style and unhealthy diet can substantially increase your risk of gaining extra pounds. Everyone is at risk for obesity and you can minimize your risks even further with a proper diet.

 

The FTO gene

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SNP markers around the FTO gene appears to be linked exclusively with fat tissue and BMI. A faulty version of this gene causes energy from food to be stored in excess in fat cells. In research, when this faulty gene was knocked out in mice, they became 50% leaner and burned more fat while sleeping despite the fact that their diet and exercise stayed the same.

What You Can do to Decrease your Risk

It would be wise to maintain healthy lifestyle habits to protect yourself from the odds.

Assess yourself Keep track of your weight and BMI and try to stay in the ”healthy” range.

Genetic testing and personalized diet plan Did you know that people who used genetic testing as part of their weight loss plan lost 2.9 times more weight and reduced their waist size by more than 2.2 times than those who didn’t? For maximum results, download the diet plan app if you are concerned about your weight.

➣ Don’t drink your calories One of the most natural and healthiest ways to keep off unwanted pounds is to reduce or even eliminate sugar laden beverages such as carbonated soda for healthier, low calorie options such as green tea. This way you can still have your slice of cake without doubling sugar and calorie intake with a calorie heavy beverage

 ➣ Be active Staying physically active not only burns calories but it keeps your metabolism up and boosts mood and productivity

Focus on smaller portion sizes People in westernized countries often eat until they feel full, which is bad for weight loss. Try to stop eating right before you get that full feeling to avoid overeating.

Replace calorie heavy, low nutrient foods with fruits and vegetables Eating a lot of food in moderation isn’t bad, but it matters what kind of food you put in your body. Low fat, low calorie food items like vegetables are a great source of energy.

Myths and Fun Facts

✓Overweight and obesity are linked to more deaths worldwide than underweight

✓ Infants and children who are overweight are more likely to be overweight or obese as adults

✓Now that research is showing that genes are closely tied with weight, scientists are working on treatments that can reverse this genetic trait

People who lost 10% of their body weight reported a significant increase in their sex lives (Duke University Medical Center)

✓5 % of Americans said they would rather lose a limb or go blind than be overweight

ADHD is Genetic

Have trouble concentrating? What about staying organized or controlling your behavior? These might be symptoms of ADHD. The percentage of children with this diagnosis have skyrocketed in recent years, and some children and even adults live their entire lives without officially being diagnosed.

Evidence from research show that ADHD is more of a genetic disorder, as there are many genes linked to ADHD. Although each play a small role, when added up with each other and combined with other complex factors from the environment , they can have a substantial impact on the overall risk.  Attention deficit disorder is a heritable disease, but  does not have significant correlation with parenting style. Luckily, treatment is available.

What are the symptoms of ADHD/ADD?

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What Can You Do?

ØConsult professional advice. ADHD is a disorder that requires the diagnosis of a physician. Some people with ADHD struggle with their jobs and relationships until they receive a diagnosis and get help. This can drastically improve your productivity and overall quality of life.

Ø Be aware that ADD/ADHD can overlap with other behavioral disorders.  A person with ADHD is 6 times more likely to have another psychiatric or learning disorder like depression, anxiety or Asperger’s.

Ø Exercise regularly. Exercise releases feel-good neurotransmitters including dopamine and serotonin, which helps with attention, memory, mood and cognition. This is important because serotonin and dopamine imbalance are thought to cause ADHD. However, the best exercises that raise neurotransmitter levels are aerobic activities such as running, swimming and dancing. Martial arts can improve the synaptic networks in the brain as well as boost serotonin levels.

Ø Eat ADHD helpful foods. Food can improve or worsen concentration and other similar ADHD symptoms. Eat a high-protein diet such as eggs, nuts, lean meat, omega-3 fatty acids, and complex carbohydrates such as vegetables.

Ø Avoid food additives and artificial colors, and sugar. Some studies have shown that some food coloring ( especially red and yellow) increased hyperactivity in children. Overall, the American Acadamy of Pediatrics agree that eliminating food additives is a reasonable option for people with ADHD.

Ø Create a routine and follow it.

Ø Love yourself and surround yourself with positive people who make you feel good. It is proven that love, positive feelings and nurturing drastically improves ADHD symptoms in children while agitation, stress and neglect worsen it. Set goals, complement, and treat yourself.

Ø Take a Time-Out from your electronic devices. Children and adults with ADHD often find that their symptoms worsen with increased technology and screen use. Put those iPhone and iPads away when it’s close to bedtime.

 

People Don’t Like You? Blame Your Genes

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Do people tend to like you?

Do you believe you are a kind, empathetic person? Your genes may be able to tell you the honest answer. In facts, there is a gene that is so influential in our socio-emotional sensitivity, that in one research, people were able to observe and  accurately judge whether a complete stranger had the “empathy” gene in under 20 seconds.  Multiple studies have proven that we are genetically predisposed to how kind we are.

Empathy and kindness lies in our genes. Oxytocin, dubbed “the cuddle chemical” or “love hormone” is a hormone associated with trust and is necessary for forging intimate relationships with loved ones. The OXTR gene, or the oxytocin receptor gene has three variants- A and G and AG and each are strongly correlated with a certain social behavior.

You are one of three types of people: GG, AG, or AA

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The GG Variant People

  • Predisposed for empathy and kindness
  •  Displays altruistic and charitable behavior
  •  Greater ability to cope with stress [PMID 19934046]
  •  Greater parenting skills and maternal sensitivity to children [PMID 19015103]
  •  Reduced risk for social anxiety and autism [PMID 20724662]
  •  Better social and communication skills; more likeable by strangers at first impression
  •  Optimistic
  • Displays more pro-social behavior
  •  Less lonely [PMID 19376182]
  • Better able to discern the emotional state of others [PMID 19934046]

 

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The AG or AA Variant People

  • Less pro-social physical and verbal cues that display empathy
  •  increased risk for impaired social interaction & communication [PMID 20724662]
  •  Twice as less likely to be charitable and altruistic, especially under stress or fear
  •  Less trusting
  •  Does not handle stress well
  •  Less maternal sensitivity and parenting ability [PMID 19015103]
  •  Feels more lonely and more emotionally co-dependent on others  [PMID 19376182]
  • Higher risk for social anxiety

 

However, social behavior is influenced by other genetic factors and many non genetic factors as well, such as culture, environment, and childhood experiences. Even though this genetic marker is strongly associated with socio-emotional sensitivity and well-being, this does not mean you absolutely have the associated social behavior. However, it is interesting to note all the different research that manifested from this gene.

The Significance of this Gene

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Oxytocin is both a hormone and a neurotransmitter that influences social and emotional processing throughout our body. It is dubbed the “cuddle hormone” because it is released when two people deeply bond. OXTR is an oxytocin receptor gene that has two variants- G and A- that is associated with  empathy and stress reactivity. Due to genetic variation, people can be either GG, AA or AG. Compared with people with the homozygous GG allele, people with AG or AA allele showed far less empathy and higher stress reactivity. Injections of oxytocin increased prosocial behaviors, generosity, feelings of trust and empathy in humans. If this OXTR gene is completely knocked out (eliminated) in lab animals, they display aberrant social behavior, increased aggression and offspring neglect.

 

  • Even slight genetic variation can quickly be noticed by others- even complete strangers. In one research, strangers watched a 20 second silent recording of 23 couples interacting with each other and judged how trustworthy and likeable someone seemed based on prosocial traits. In the 10 least trusted people, 9 had at least one copy of the A genotype.

 

  • Mice that has the OXTR receptor gene completely knocked out showed aggressive and aberrant behavior and even refused to acknowledge it’s own offspring.

 

  •  Those with at least one copy of the A genotype is more likely to have an autism diagnosis.

 

  •  Study examining the relationship between 176 mothers and their children showed that mothers with the GG genotype has a significantly more sensitive parenting style than those with AG or AA genotypes. [PMID 19015103]